Smallpox Vaccination – Adverse Reactions: Accidental Implantation- Clinical Manifestations

Accidental Implantation: Clinical Manifestations


Implanted lesions progress in the same fashion as the primary vaccination. Notes on clinical manifestations for patients with pre-existing conditions follow. Clinical Manifestations for Patients with Pre-Existing Conditions

	Condition	Notes

	Cell-mediated immune dysfunction	In patients with cell-mediated immune dysfunction, each lesion progresses without an inflammatory response, does not heal, and expands.

	Eczema or disrupted skin	In individuals with eczema or disrupted skin, the lesions tend to be confluent and massive in extent.

	Prior inflammatory eye disease	Periorbital, conjunctival and corneal lesions are seen in those with prior inflammatory eye disease. The periorbital and conjunctival lesions undergo the same evolution as the primary in skin and mucosa, whereas the corneal infection causes ulceration and ultimate cloudiness.