Congenital
vaccinia is a very rare event.
Despite large-scale vaccination campaigns in the past
that undoubtedly resulted in inadvertent vaccination
of many pregnant women, fewer than 50 cases of congenital
disease have been recorded in the literature.
The third trimester of pregnancy appears to be a critical
time for the risk to the fetus of congenital vaccinia,
although there have been rare reports of vaccination
earlier in pregnancy resulting, at birth, in evidence
of disease having been present.
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