Erythema Multiforme: General

A variety of rashes occur in a large number of vaccinees 1-2 weeks after vaccination. Actual frequencies from a 1968 US survey were:

Accidental Implantation Frequencies
(1968 US Survey)
Ages in Years # per million
primary vaccinees
< 1 1350
1-4 1000
5-19 630
20+ 875

The rash is erythematous and pruritic in most instances and is most intense surrounding the vaccination site. The degree of erythema is intense and the rash may be raised or flat, with an urticarial border. The rash tends to be symmetrical and often involves the palms and soles.

Intense itching may accompany the rash and scratching can lead to bacterial superinfection.

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