Generalized
vaccinia is the result of the systemic spread of virus
from the vaccination site. Despite the appearance of
the lesions, it is a totally benign complication of
primary vaccination. Its frequency is not known but
it is believed to be rare.
The literature is confusing as this term has been used
to describe this benign event as well as more serious
and even lethal complications (eczema vaccinatum, other
implantations, and progressive vaccinia). The term ìgeneralized
vacciniaî as used here will refer only to the
rare, benign complication itself.
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