The
exact frequency of this complication following vaccination
is not known. Most believe it to be rare based on anecdotal
information and infrequent reports in the literature
as well as the experience of those who have specialized
in the care of individuals with complications of vaccination.
Since most of these individuals are children, and most
were seen and studied at a time when immunologic knowledge
was less complete than at present, characteristics that
enhance susceptibility are not known for certain. It
is likely that many of these children had subtle and
minor immunologic abnormalities that permitted some
extension of virus spread, but not morbid or lethal
disease.
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