Most
instances of generalized vaccinia, particularly if the
lesions are few, require no specific therapy. In some
cases, with extensive lesions, or in recurrent disease,
Vaccinia Immune Globulin (VIG) should be administered
in an initial dose of 0.6 ml per kg body weight. Rarely
is it necessary to administer more than one course with
recurrent disease.
If an antibody (B-cell) deficient state or another immunologic
abnormality is diagnosed, then both VIG therapy for
the viral disease and appropriate therapy for the immunologic
deficiency must be decided in consultation with an immunologist.
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