Topical
antiviral agents are the treatment of choice. The best agent
to use should be determined in immediate consultation with
an experienced ophthalmologist. Current information suggests
that a combination of an antiviral nucleoside and interferon
topically speeds healing. Agents such as vidarabine, trifluridine
or acyclovir have been used. Some ophthalmologists recommend
concurrent debridement or other physical or physicochemical
methods of treatment, but these methods have not been adequately
investigated to make firm recommendations.
Vaccinia Immune Globulin (VIG) should not be used
in vaccinia keratitis. There is some evidence in humans and
animal models that more extensive corneal clouding can occur
following VIG therapy.
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