Vaccinia virus can be implanted into diseased or injured conjunctiva and cornea resulting initially in viral replication with ulceration and ultimately in an antigen-antibody interaction leading to corneal cloudiness. Ten days after transfer the clinical signs of infection appear.
Untreated there may be considerable scarring as the lesion heals with significant impairment of vision.
VIG is contraindicated for use in vaccinial keratitis.
If Vaccinia Immune Globulin (VIG) is administered an antigen-antibody reaction is accentuated in the cornea and may result in significantly more cloudiness than in the normal healing process.
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