Progressive Vaccinia: General

Progressive vaccinia is the most severe complication of smallpox vaccination. It is almost always life threatening.

Progressive vaccinia is the preferred designation for this complication although, in the past, it has sometimes been termed:

Vaccinia necrosum
Vaccinia gangrenosa
Disseminated vaccinia

Rare in the past, it may be a greater threat today, given the larger proportion of susceptible persons in the population.

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